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KMID : 0988920180160030400
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Intestinal Research
2018 Volume.16 No. 3 p.400 ~ p.408
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Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
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Yeo Seong-Jae
Lee Hyun-Seok
Jang Byung-Ik
Kim Eun-Soo
Jeon Seong-Woo
Kim Sung-Kook
Kim Kyeong-Ok
Lee Yoo-Jin
Lee Hyun-Jik
Park Kyung-Sik
Jung Yun-Jin
Kim Eun-Young
Yang Chang-Heon
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Abstract
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Background/Aims: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD).
Methods: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative colitis and 101 with Crohn’s disease). Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels were measured and compared with those of 1,100 sex- and age-matched controls.
Results: The prevalence of chronic HBV infection (positive HBsAg, positive anti-HBc, and negative anti-HBs results) and past infection (negative HBsAg, positive anti-HBc, and positive or negative anti-HBs results) were not significantly different between the patients and controls (chronic HBV infection: IBD, 3.8% vs. control, 4.9%, P=0.596; past infection: IBD, 26.2% vs. control, 28.8%, P=0.625). The patients with IBD aged <20 years were at a higher susceptibility risk (nonimmune) for HBV infection than the controls (IBD, 41.5% vs. control, 22.4%; P=0.018). In the multivariate analysis, an age of <20 years (P=0.024) and symptom duration of ≥12 months before diagnosis (P=0.027) were identified as independent risk factors for nonimmunity against HBV infection.
Conclusions: The patients newly diagnosed with IBD were susceptible to HBV infection. The frequency of nonimmunity was high, especially in the patients aged <20 years and those with a longer duration of symptoms before diagnosis. Therefore, it is necessary to screen for HBV serologic markers and generate a detailed vaccination plan for patients newly diagnosed with IBD.
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KEYWORD
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Inflammatory bowel disease, Colitis, ulcerative, Crohn disease, Hepatitis B virus, Vaccination
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